B27 negative but with sacroiliac arthritis treatment should be combined with their own conditions, treatment methods include drug therapy, physical therapy, surgical treatment, etiological treatment and so on. B27-negative cannot exclude ankylosing spondylitis, but only indicates that the possibility of having ankylosing spondylitis is low, and ankylosing spondylitis is easy to cause sacroiliac arthritis. 1. Medication: Non-steroidal anti-inflammatory drugs such as ibuprofen and diclofenac sodium can be used for pain, and cartilage-protecting drugs such as glucosamine sulfate can be tried. 2. Physical therapy: heat therapy, hydrotherapy, infrared ray, ultra-short wave, electrical stimulation can enhance local microcirculation, relieve muscle ligament spasm and tension, and relieve pain and other symptoms. 3. Surgical treatment: localized small needle treatment or closed treatment can be carried out. If the above treatments are not effective and the joints are severely diseased, arthroscopic joint flushing and osteochondral transplantation can be considered. 4. Treatment for the cause of the disease: for example, in ankylosing spondylitis, non-steroidal anti-inflammatory drugs such as celecoxib, immunosuppressants such as sulfasalazine, methotrexate, etc., glucocorticoid such as dexamethasone, etc., and biologics such as tumor necrosis factor antagonist adalimumab. B27 negative but with sacroiliac arthritis treatment should be combined with their own situation, it is recommended to timely visit the hospital, under the guidance of the doctor to choose the appropriate treatment program, so as not to delay the condition. All of the above drugs should be used under the guidance of a doctor.