Bone metastasis of lung adenocarcinoma suggests that the tumor cells have spread and metastasized to distant places, and the condition has deteriorated with poor prognosis, which is more serious and needs active treatment to improve the prognosis of the disease. Lung adenocarcinoma with bone metastasis can be treated with radiotherapy, targeted therapy and immunotherapy to improve the prognosis of the disease, which can shrink the tumor lesions, inhibit the growth of the tumor, improve the quality of life of the patients and prolong the survival time of the cancer patients. Chemotherapy drugs that patients can choose include paclitaxel, cyclophosphamide, cisplatin, etc.; targeted drugs include gefitinib, erlotinib, etc., and immunotherapy drugs include pabolizumab. The drugs need to be used under doctor’s advice and in combination with one’s own situation, and those who have adverse reactions need to consult doctor in time, and those who are allergic to the drugs are forbidden to use them. Therefore, bone metastasis of lung adenocarcinoma is relatively serious, and it is recommended that patients relax their mind and take active treatment.