There is no inevitable relationship between particle implantation and when to use targeted drugs; it needs to be judged according to the results of genetic examination, the patient’s physical condition, and whether there are contraindications. Particle implantation belongs to radiotherapy, which mainly uses radioactive particles to implant into the lesion to kill tumor cells and inhibit tumor growth. Particle implantation itself generally does not affect the use of targeted drugs, and most patients do not need to stop taking drugs during particle implantation. Targeted drugs need to be selected according to the results of genetic testing, the patient’s physical condition, and previous treatment; targeted drugs also have certain contraindications, if the patient has a combination of uncontrollable high blood pressure, cardiorespiratory failure, liver and renal failure, it is generally not recommended to use targeted drugs. Particles, as well as targeted drugs, are different modalities in the treatment of malignant tumors; it is necessary to comprehensively assess the patient’s physique and condition under the guidance of a specialist physician to formulate an individualized treatment plan.