Lumps on the legs can be caused by the following diseases: First, there is a history of varicose veins in the lower extremities, and as the disease evolves, the local dilated vein masses will gradually increase in size, and there will also be blood pooling and thrombosis, which will stimulate the local skin and form thrombophlebitis, with a significant local inflammatory reaction. Patients will show localized lumps, even with significant pain and fever, and should be treated with systematic anti-inflammatory therapy and, if necessary, surgery. Secondly, tumors occurring in subcutaneous tissues, commonly lipomas, but also fibromas, especially neurofibromas, may cause significant pain and numbness in the lower extremities, as well as significant discomfort when moving. The most effective treatment for this disease is surgical excision, which is usually performed under local anesthesia and requires pathological histological examination and regular review after surgery.