Livin is a recently discovered new member of a family of proteins that inhibit apoptosis. Its gene is localized on chromosome 20q13 and is 4.6 kb in length, encoding proteins of 298 and 280 amino acids, respectively. It contains a BIR region and a Ring region. The Ring structural domain is not involved in the inhibition of apoptosis, but has an important role in the rational distribution of Livin in the cell, and the BIR structure inhibits the TNF-α and cytochrome C pathways. the BIR functional region of Livin is essential for its anti-apoptotic activity, and the structure has four α-helices and a zinc finger structure that maintains its three-dimensional structure The BIR domain is also covered by a number of charged residues, most of which are shared by members of the IAP family. It was found that Livin is not expressed or is lowly expressed in most normal adult tissues, but is highly expressed in many human malignancies such as melanoma, breast cancer, prostate cancer, and lymphoma, suggesting that this gene may play an important role in the development of tumors. The etiology and pathogenesis of PCa have not yet been elucidated. With the in-depth study of the regulation of apoptotic pathway genes, the study of the relationship between apoptosis suppressor genes and the occurrence and development of PCa has gradually begun to attract attention. Krajewska et al. found that the apoptosis suppressor genes Livin, XIAP, cIAP1, cIAP2, and survivin are commonly up-regulated in PCa , suggesting that upregulated expression of apoptosis suppressor genes is an early event in the process of PCa development and is associated with the onset and progression of PCa. In this study, RT-PCR results showed that Livin was highly expressed in PCa tissues, but not in normal prostate tissues; immunohistochemical results showed that the positive expression rate of Livin protein in 62 PCa specimens was 59.7%, and the positive expression rate of Livin protein in the low differentiation group was significantly higher than that in the high differentiation group, and the difference was statistically significant (P<0.05); between the middle and high differentiation groups The positive expression rate of Livin protein was not statistically different between the middle and high differentiation groups and between the low and middle differentiation groups (P>0.05); the later the clinical stage, the higher the positive expression rate of Livin protein (P<0.05), and the expression of Livin gene was related to the grading and stage of PCa. The results of this study suggest that Livin gene plays an important role in the occurrence and development of PCa; Livin gene may also have a certain relationship with the prognosis of PCa, the higher the expression of Livin, the higher the malignancy of PCa and the worse the prognosis; the results need to be confirmed by further studies.