Griscelli syndrome 2 is a rare genetic disorder that can cause significant damage to multiple systems throughout the body. Griscelli syndrome 2 is a hereditary disease. Patients suffering from this disease often show generalized hypopigmentation and can induce fatal hemophagocytic syndrome, which manifests itself as fever, hepatosplenomegaly, respiratory symptoms, enlarged superficial lymph nodes, jaundice, rashes, plasma membrane cavity effusion, petechiae or hemorrhagic dots on the skin, symptoms of central nervous system, and impaired renal function, etc. Patients should follow the doctor’s instructions to rest and keep warm. Patients should follow the doctor’s instructions in daily life, pay attention to rest and warmth, appropriate outdoor activities, and try not to go to crowded places; after a period of remission, they should follow the doctor’s instructions for review and keep abreast of the changes in their condition, and once there are new changes in their condition, they should go to the hospital in time to consult the doctor and take the appropriate diagnostic and therapeutic measures.