The appearance of small bumps on the nose after taking afatinib must firstly be closely observed, and secondly, symptomatic treatment is needed, and in serious cases, the dosage of the drug needs to be reduced or the treatment needs to be interrupted. 1. Pay attention to observation. Rash after the use of drugs, generally considered to be an adverse reaction to the drug, the symptoms are mild, the main attention is to do a good job of sunscreen treatment, and keep the skin clean, avoid too much stimulation. 2. Symptomatic treatment. Local topical emollients can play a role in early intervention, such as vitamin E milk. Topical antibiotics, such as mupirocin cream, can be used when there are obvious signs of infection. 3. Reduce the dosage or discontinue treatment. If the symptoms of adverse drug reactions persist and show signs of worsening, it is important to reduce the dosage or interrupt the treatment. To ensure the safety and efficacy of the medication, it is important to follow the doctor’s instructions.