Waking up in the middle of the night with tightness in the chest may be caused by heart disease, respiratory disease, sleep apnea syndrome, and patients should consult a doctor in time to clarify the cause of the disease. 1. Heart disease: can cause sleep in the middle of the night suddenly woke up chest tightness heart disease has heart failure, variant angina, etc., the patient should consult a doctor in a timely manner, under the guidance of the use of drugs. (1) heart failure: various causes of the heart pumping function decline, pumping blood can not meet the body’s needs, the patient will have difficulty breathing, coughing, coughing sputum, as well as waking up in the middle of the night suffocation, can be prescribed by the use of captopril, hydrochlorothiazide and other drugs for treatment. (2) Variant angina: that is, the coronary artery supplying blood to the heart undergoes transient spasm, and the patient will wake up with chest tightness, chest pain, and fainting during sleep, which can be treated with nifedipine, amlodipine, and isosorbide mononitrate as prescribed by the doctor. 2. Respiratory diseases: when patients have bronchitis, pneumonia, bronchial asthma, chronic obstructive pulmonary disease, due to respiratory restriction, patients will have chest tightness and wake up, and should seek medical treatment in time. 3. Sleep apnea syndrome: mainly manifested as snoring while sleeping, daytime sleepiness, chest tightness and waking up and other symptoms, mostly seen in the more obese people, when the symptoms of such people are more serious, they should be operated under the guidance of the doctor. Sleeping in the middle of the night to wake up with chest tightness, need to actively seek medical attention, follow the doctor’s instructions reasonable treatment.