Diffuse hepatic echogenic changes are often indicative of acute and chronic liver injury and may suggest fatty liver, viral hepatitis, alcoholic hepatitis, etc. 1. Fatty liver. When blood fat is too high and exceeds the normal capacity of liver cells to process fat, excess fat is deposited in the liver and fatty liver is formed, which in turn causes diffuse liver lesions. It can be diagnosed or ruled out by taking into account the patient’s body type, lipid level and past medical history. 2. Viral hepatitis. When infected by hepatitis virus, part of liver cell necrosis, the liver gradually fibrosis and diffuse lesions. 3. Alcoholic hepatitis. In patients with chronic alcoholism, diffuse hepatic lesions can be suggested in ultrasound when the liver suffers long-term alcohol damage. It is recommended that the diagnosis of diffuse echogenic changes in the liver should be made in a timely manner, and the cause of the disease should be clarified and then treated accordingly.