Rough and granular skin on thighs may be related to chronic eczema, keratosis pilaris, ichthyosis and so on. 1. Chronic eczema: rough skin with granularity, skin hypertrophy, roughness, mossy changes, may be accompanied by itching and other discomforts. 2. Perifollicular keratosis: manifested as small papules centered on hair follicles, in the middle of which there may be hair trunks, mostly appearing in patches, similar to moss-like changes, which may be manifested as roughness with granularity. 3. Ichthyosis: light brown, scaly rash, dry, flaky skin, can also be manifested as rough and granular. It is recommended that patients go to the hospital in a timely manner, under the guidance of the doctor for treatment, do not blindly use their own medication.