In China, the proportion of early gastric cancer is 10%-20%, and the majority of middle and late gastric cancer is 80%-90%, so the majority of gastric cancer patients are in middle and late stage when they are found. The common clinical symptoms of late gastric cancer are as follows: 1. Pain is one of the most common symptoms of late gastric cancer patients, which seriously affects patients’ quality of life. The pain site is the heart fossa area, sometimes it only manifests as upper abdominal discomfort or hidden pain, and the more typical pain is pain without regularity, which is not relieved even by eating. Once tumor metastasis occurs, pain in the corresponding area will appear. 2. Nausea and vomiting are also common symptoms of advanced gastric cancer, because gastric cancer is affected by pylorus, pylorus obstruction is more common. Due to the difficulty in eating and tumor consumption, most patients have wasting. In addition, patients are also found to have anemia, which eventually develops into cachexia. 4. Upper gastrointestinal bleeding is the most common emergency of advanced gastric cancer, which is manifested as tarry stool. If the fecal occult blood test is positive, symptoms such as vomiting blood and black stool will appear.5. If advanced gastric cancer metastasizes to other parts, such as liver metastasis, pain, ascites, jaundice, abdominal distension, etc. may appear.