Girls with severe spot baldness can be regulated by general treatment, drug treatment, physical therapy and other methods. 1. General treatment: first of all, we should pay attention to actively searching for the cause of the disease, as well as removing the triggering factors, such as actively treating diabetes, neurasthenia, infections and other causes; secondly, we should pay attention to maintaining a pleasant mood and lifting the psychological burden. 2. Drug therapy: including local drugs and systemic drugs. (1) local drugs: such as local injection of glucocorticoids, can reduce perifollicular inflammation, but easily lead to local pain and skin atrophy and other adverse reactions, commonly used drugs are dexamethasone, betamethasone, etc.; can also be combined with topical glucocorticoid medications, such as hydrocortisone ointment, triamcinolone acetonide cream, and so on. (2) Systemic medication: For the spot baldness caused by mental tension, anxiety, etc., sedatives, such as diazepam and lorazepam, can be given for relief. (3) Physical therapy: such as common ultraviolet irradiation, photodynamic therapy, excimer laser, etc., all have a certain therapeutic effect on baldness. As each patient’s physique and condition is different, it is recommended to consult the hospital in time, standardize the treatment under the guidance of the doctor, and the drugs should be used according to the doctor’s instructions, do not self-medication.