Cranial defects are usually caused by traumatic brain injury and lesions inside the brain, which are often caused by some traffic accidents, natural disasters, heavy objects, etc. Cranial lesions are commonly caused by cerebral hemorrhage and cerebral infarction, which may leave cranial defects after emergency debridement surgery. Long-term cranial defects pose a great risk to patients’ health and psychological well-being, and some patients may have depression or bulge at the defective area, which may lead to a series of cranial defect syndromes, seriously threatening patients’ health and causing psychological trauma due to the extremely unattractive appearance. The neurosurgical guidelines clearly state that skull defect of 3cm*3cm or more requires cranial repair surgery as soon as the patient’s condition has recovered to a stable level. Although cranial repair surgery can be carried out in most general hospitals, because the surgery involves the human scalp, blood vessels, brain tissue, nerves and other important organs, and in addition, postoperative complications such as rejection infection have been found in some patients, so patients should not take it lightly and must choose advanced and mature cranial repair technology. It is reported that polyether ether ketone peek cranial repair, with new high tech molecular peek as implant material, takes embedded repair method, smooth articulation after surgery, strong resistance to striking and low rate of rejection infection. At the same time, we carry out personalized optimization design of materials and innovation and upgrade of surgical techniques, introduce the concept of aesthetic plastic surgery, and make personalized cranial repair and appearance plastic surgery plan for each patient to ensure precise repair and natural and beautiful symmetry on both sides of the shape after surgery. The cost of skull repair surgery is based on the size of the patient’s defect, the difficulty of the surgery, the presence of other comorbidities, the specific treatment care and other factors.