Premature ejaculation is treated with 5-hydroxytryptamine reuptake inhibitors such as dapoxetine with good efficacy and rapid results. 5-Hydroxytryptamine reuptake inhibitors such as dapoxetine are oral prescription medications used to treat premature ejaculation (PE) and are the first line of treatment for PE. Oral administration of this class of drugs about 1 hour to 2 hours before sex can prolong ejaculation time by more than 2.5 times, with a rapid rate of action and good efficacy. Common adverse reactions to this class of drugs include headache, diarrhea, and nasal congestion. However, it should be noted that this class of drugs is contraindicated in people with a known allergy to the product, in patients with a significant pathological condition of the heart, in patients with moderate and severe liver damage. This class of drugs should also not be used in conjunction with thioridazine, strong cytochrome P450 3A4 inhibitors, and monoamine oxidase inhibitors. Specific use of the drug should follow the clinician’s instructions to avoid adverse events.