Hundreds of hiccups a day are mostly considered to be due to pathologic factors such as intracranial lesions, mediastinal disorders, and gastrointestinal disorders. Hiccups are medically known as hiccups and are caused by spasmodic contraction of the diaphragm. Under normal circumstances, it can be caused by eating too fast or too full, consuming food that is too hot or too cold, drinking alcohol and other factors, but this is usually physiological, and can be relieved soon, not persistent hiccups. Hundreds of hiccups a day are mostly due to pathologic factors. 1. Intracranial lesions: cerebral hemorrhage, meningitis, encephalitis, brain tumors and other diseases will affect the innervation of the phrenic nerve to the diaphragm, resulting in diaphragmatic spasm, and the symptom of hundreds of hiccups a day. 2. Mediastinal diseases: such as mediastinal tumor, mediastinal lymph node enlargement, esophagitis, esophageal cancer, pericarditis, pneumonia, myocardial infarction and other diseases will stimulate the diaphragm to produce persistent spasm, resulting in hundreds of hiccups a day. 3. Gastrointestinal diseases: gastritis, peptic ulcer, pyloric obstruction, gastric cancer, gastroesophageal reflux disease and other gastrointestinal diseases are usually accompanied by excessive secretion of gastric acid, which stimulates the diaphragm, and can also cause hundreds of hiccups a day. In addition, medications, generalized paralysis, psychiatric factors, alcoholism, and other disorders may also lead to hundreds of hiccups a day. If the patient has long-term or recurrent hiccups, it is recommended to consult a doctor in time to identify the cause of the disease and carry out targeted treatment.