Usually you will not urinate too much on clarithromycin, but you may experience adverse reactions such as abdominal pain, diarrhea, and nausea. If excessive urination occurs at this time, it may be the result of drinking too much water or diseases such as urethritis or cystitis. Clarithromycin is a common macrolide antibiotic, usually, taking clarithromycin does not cause excessive urination. However, some patients taking Clarithromycin may experience common adverse reactions such as abdominal pain, diarrhea, nausea, vomiting, taste disorders, headache, and indigestion. Therefore, if patients experience excessive urination during medication, it is mostly considered that it is not related to the drug and may be a physiologic frequent urination caused by drinking too much water. However, it may also be caused by urethritis, cystitis, hyperthyroidism, urinary stones and other diseases. Patients need to strengthen the management of private hygiene at this time, so as not to aggravate the condition. In summary, patients who eat clarithromycin urinate more need to go to the hospital, improve a series of examinations, clarify the specific causes, and cooperate with doctors to actively treat.