Hepatic lobe atrophy is the destruction of the structural function of the liver, which can also be observed by imaging to have a reduced shape. The causes are mostly due to diseases of liver ischemia and bile duct blockage, most commonly such as intrahepatic bile duct stones that cause liver atrophy. The destruction and reconstruction of the liver structure due to cirrhosis in some patients can also cause lobe atrophy. The main laboratory methods to check for hepatic lobe atrophy are: 1. Routine blood tests In hypersplenism, there is a decrease in whole blood cells. White blood cells are reduced, often below 4,0×109/L (4000). Platelets are mostly below 50×109/L (50,000). Most cases show normocytic anemia, and a few cases of hepatic lobe atrophy may be macrocytic anemia. 2. Urinalysis Urine test is positive for urinary bilirubin/urinary bilirubinogen when jaundice is present. 3. Routine examination of ascites Ascites is leaky fluid with a density of 1,018 or less, negative Lister reaction, cell count of 100/mm3 or less, and protein quantification of less than 25 g/L. 4. Liver function test Liver function is complex. There are many clinical tests, but it is still difficult to reflect the full functional status. Various laboratory results need to be combined with clinical manifestations and other tests for comprehensive analysis.