A slightly hypoechoic area in the left lobe of the liver with unclear borders and uneven echogenicity is usually an ultrasound term for the liver, which may be benign or malignant, and further investigations should be performed under the supervision of a doctor to make a definitive diagnosis. Slightly hypoechoic left liver” indicates that there is an area in the liver with lower than normal liver echoes, which may be benign lesions such as non-uniform fatty liver, hepatic hemangiomas, hepatic adenomas, hepatic abscess, focal nodular hyperplasia of the liver, inflammatory pseudotumor, etc., or malignant lesions, such as primary or metastatic hepatocellular carcinoma. Uneven internal echogenicity on liver ultrasound indicates that there are parenchymal changes in the liver, and “unclear boundary” usually does not determine whether the lesion is benign or malignant, and further investigations, including enhanced CT, enhanced MRI, and puncture biopsy of the lesion area, are needed to make a clear diagnosis. The diagnosis should be clarified. Therefore, if a slightly hypoechoic lesion with unclear border and uneven internal echogenicity is found in the left inner lobe of the liver, the patient should consult a doctor for further examination to make a clear diagnosis and timely treatment.