Severe chronic inflammation of the mucosa with erosion is an endoscopic description of gastric or intestinal mucosal lesions, which should be treated by improving dietary habits, eradicating H. pylori, and protecting the gastrointestinal mucosa. 1. Eradication of Helicobacter pylori: It is recommended that patients check for Helicobacter pylori, and if positive, undergo debacterization treatment. Currently, the recommended eradication therapy is generally a quadruple therapy of 10 or 14 days, including proton pump inhibitors (e.g., omeprazole, rabeprazole, etc.), bismuth (e.g., bismuth potassium citrate, bismuth pectin), and two antimicrobial drugs (e.g., amoxicillin, clarithromycin, etc.). 2. Protect the mucosa of gastrointestinal tract: If there is a lesion of gastric mucosa you can take some gastric mucosal protectants orally, such as aluminum phosphate gel, and drugs to inhibit gastric acid secretion such as famotidine tablets, omeprazole, rabeprazole and so on. If there are lesions in the intestinal tract, you should use mucosal protectants that have the effect of protecting the whole digestive tract, such as teprenone capsules. 3. Improve dietary habits: avoid rough, strong spicy and hot food, and chili, pepper, mustard, etc., in order to reduce the stimulation of the mucous membrane; eat more fresh fruits and vegetables, eat less or do not eat smoke, pickled food, reduce the intake of salt. At the same time life should pay attention to try not to drink alcohol and smoking. It is recommended that patients go to a regular hospital, under the guidance of a physician, to give targeted treatment after the cause is clear, not blindly use their own medication.