Analgesics are drugs that act on the central nervous system and can selectively relieve pain at doses that have no significant effect on hearing, touch and vision and keep consciousness. These drugs are divided into opioid alkaloid analgesics, synthetic analgesics and non-narcotic analgesics. Q: Why should analgesics not be taken frequently? A: Long-term overdose of analgesics is harmful to the human body, and its harm is mainly manifested in the following three aspects: (1) Long-term use of analgesics can make the human body dependent on the drugs, and adverse reactions such as yawning, cold sweats, increased pain, mental tension and physical discomfort can occur. (2) Excessive or long-term use of analgesics, especially antipyretic analgesics, can easily lead to damage to the gastric mucosa and ulcers. Analgesics can inhibit the synthesis of prostaglandins in the body, which can cause damage to the digestive tract while playing a pain-relieving role and making the body lose the protective effect of prostaglandins. (3) Long-term use of analgesics can disrupt the coagulation system of the body, resulting in prolonged bleeding time and inducing bleeding in the digestive tract and skin. The degree of risk of bleeding is related to the sexe and age of the patient using analgesics. The risk of bleeding and perforation of the gastrointestinal tract after analgesic use is usually higher in males and older people, and the higher the dose of analgesics used, the greater the risk. So, how should analgesics be used? In fact, analgesics do not relieve the cause of the disease. Generally, analgesics are only indicated for patients with very high fever or chronic dull pain, such as toothache, headache, neuralgia, muscle pain, joint pain and menstrual pain. Generally, when the purpose is to relieve pain, the use of analgesics should be limited to 5 days, while for the treatment of rheumatism and muscular and skeletal diseases, the medication must be used under the guidance of a doctor. Q: What should I pay attention to when applying analgesics? A: Special attention should be paid to the use of analgesics: (1) Pregnant women, nursing mothers and children under 3 years of age should not be used or used with caution; elderly people with hypertension, arteriosclerosis and renal dysfunction should use analgesics that do not have hypotensive effects and do not inhibit prostaglandin secretion, such as sulindac. (2) Combined renal dysfunction should be used with caution or not, if necessary, the dose should not be too large; those with bleeding tendency and history of upper gastrointestinal bleeding or perforation should be used with caution or prohibited; those who may have rash, asthma and other adverse reactions after use should be used with caution; those with gastric or duodenal ulcer disease should be prohibited. (3) Patients who are allergic to analgesics or the ingredients contained therein should not use other analgesics of the same type, because cross-allergic reactions may occur with the use of similar drugs. (4) To avoid stimulation of the gastrointestinal tract by analgesics, analgesics should be taken after meals. When using analgesics, never drink alcohol or drinks containing alcohol because alcohol will increase the stimulation of the gastrointestinal tract and induce bleeding or ulcers in the gastrointestinal tract. (5) It should not be combined with glucocorticosteroids, as it will increase the risk of gastrointestinal diseases by two times.