Moderate consumption of barramundi is not harmful, mainly because it is easy to cause “allergic food poisoning” after leaving it for too long. Barramundi, also known as blue jack, is a common fish in our daily life, and most people will eat it after cooking or marinating. Currently, there are fewer known harmful effects of barramundi. The identified harmful effect is that the flesh of barramundi contains a large amount of histidine, which, if left for a long period of time, results in the massive decomposition of histidine into histamine, which may lead to “allergic food poisoning” after consumption by the normal population. In addition to the more common symptoms of nausea and vomiting, abdominal pain and diarrhea, muscle aches and pains, allergic food poisoning may also lead to symptoms such as facial flushing, skin rashes, itching, etc., and some patients may also suffer from decreased blood pressure, dizziness, headache and conjunctival congestion, which have a greater impact on the patient’s health. In addition to the above harms, due to the rich protein, fat and other substances in the flesh of barramundi, excessive intake may lead to indigestion in normal people, so it is generally not recommended for normal people to consume too much. People who are allergic to barramundi should not consume it.