Consider lumbar spinal stenosis, lumbar herniation, and lower extremity vascular disease. 1. Lumbar spinal stenosis: Both congenital and acquired lumbar spinal stenosis can lead to weakness and tiredness. Congenital stenosis mainly refers to the narrowing of the spinal canal, which presses on the nerve roots, leading to weakness of the lower limbs and fatigue. 2. Lumbar disc herniation: The herniated nucleus pulposus compresses the nerve roots similar to the above mentioned lumbar spinal stenosis. The nerve roots are compressed, leading to weakness and fatigue. 3. Lower limb vascular disease: the lower limbs are congested with blood after walking due to poor venous return, insufficient blood supply, and the lower limbs are prone to fatigue and intolerance of exercise. In addition, diabetic patients are prone to lower extremity arterial thrombosis or arterial occlusion, which can also lead to lower extremity swelling and weakness after activity, usually unilateral lower extremity attack. In addition, prolonged exertion can also lead to this condition. In severe cases, active medical treatment is recommended.