A well-filled gallbladder is often described on ultrasound, CT, MRI (magnetic resonance imaging), or cholangiography, suggesting that the gallbladder is in good condition. The opposite of good filling is filling defects. Stones or tumors in the gallbladder can cause filling defects in the lumen, usually the margins of the defects are neat due to stones, and most of them are irregular due to tumors. 1. Ultrasound: when the gallbladder is well filled, the wall of the gallbladder is smooth, and the cystic cavity is non-echoic; when the filling defect is manifested as a non-echoic cystic cavity with a strongly echogenic mass of stones, or a weakly or moderately echogenic solid mass. 2.CT: when the gallbladder is well filled, the wall of the gallbladder is smooth and sharp, and the cystic cavity is homogeneous and low-density; when the filling is defective, it can be manifested as a high-density calcified lesion or a mass of the same density as that of the soft tissues. 3.MRI: when the gallbladder is well filled, the performance is the same as that of CT; when filling defect, the stone is shown as a low-signal filling defect within the bile with high signal on T2-weighted imaging, and the tumor is shown as a filling defect within the soft tissue signal of the gallbladder. 4. Cholangiography: Currently, endoscopic retrograde cholangiopancreatography is commonly used, which refers to the insertion of an endoscope into the duodenal papilla via the esophagus and duodenal descending portion of the esophagus and duodenum under X-ray fluoroscopy and the injection of a contrast agent to show the biliopancreatic ducts. The bile ducts can also be visualized by injecting contrast through a “T-tube” placed after choledochotomy, and by “T-tube” cholangiography. Thus, a well-filled gallbladder can be one of the bases for identifying stones and tumors in the gallbladder.