There is no such thing as the best and fastest way to get rid of foot calluses. Foot callus refers to callus, can take general measures, medication, other treatments, surgical treatment. 1. General measures: patients usually use hot water to soak feet, to be softened callus, need to cooperate with the doctor to use a surgical blade to cut off the indicated cuticle, do not self home treatment. Secondly, need to reduce the foot skin friction, pay more attention to rest. 2. Drug treatment: patients need to use salicylic acid cream, vitamin A ointment, high concentration of urea cream and other keratolytic drugs under the guidance of the doctor. 3. Other treatments: Secondly, it can also be treated by physical measures such as liquid nitrogen freezing and carbon dioxide laser. If plantar deformity exists, orthopedic insoles should be used as prescribed by the doctor. 4. Surgery: Generally, this disease does not require surgical treatment, but for patients with foot bone deformity, it is necessary to consider foot bone correction surgery. Usually, patients with calluses need to strengthen the daily life management, keep the local dry and clean, wear the right size shoes.