Nausea that occurs during sleep for a long time and interferes with sleep may be related to chronic gastritis, gastroesophageal reflux, and chronic cholecystitis. 1. Chronic gastritis: After food enters the stomach, it cannot be fully digested and absorbed by digestive enzymes, and is transmitted to the duodenum and jejunum, resulting in delayed emptying. At this time, a large amount of food retention in the stomach will lead to nausea. 2. Gastroesophageal reflux (GERD): The sphincter muscle is damaged, so it is unable to inhibit the reflux of food from the stomach, resulting in the reflux of gastric contents. The reflux may be gastric fluid or bile, which is irritating to the esophagus and throat, causing long-term nausea and interfering with sleep. 3. Chronic cholecystitis: If you eat a lot of greasy, indigestible food, such as braised pork and pork knuckles, or if you eat too much, the gallbladder will speed up its contraction in order to digest the greasy food and discharge the more concentrated bile, which will result in high pressure in the gallbladder, so nausea may occur. When nausea occurs when sleeping for a long time and affects your sleep, it is recommended to consult a doctor for a clear diagnosis and actively cooperate with the doctor for treatment.