There is no such thing as “the best treatment for white matter demyelination”. The treatment for cerebral white matter demyelination is medication, and commonly used drugs include glucocorticosteroids, antihypertensive drugs, and lipid-lowering drugs. 1. Glucocorticoid: the purpose is to reduce edema and inhibit the damage of immune response to the cerebral white matter, commonly used drugs are prednisone acetate, dexamethasone and so on. 2. Antihypertensive drugs: to keep blood pressure stable and protect blood vessels, commonly used drugs are nifedipine, irbesartan, etc. 3. Lipid-lowering drugs: patients with abnormal cholesterol need to use lipid-lowering drugs such as atorvastatin to control cholesterol levels. 4. Hypoglycemic drugs: Chronic hyperglycemia will damage the endothelial cells of blood vessels, affecting the metabolism of brain tissues and causing cerebral leukopathy. Commonly used drugs include metformin and acarbose. 5. Folic acid: patients with homocysteinemia should supplement folic acid to promote metabolism, which can reduce the probability of cerebral white matter lesions. If the brain white matter demyelination should be timely consultation, drugs should be used in accordance with the doctor’s instructions.