The common causes of thigh pain during dysmenorrhea are endometriosis such as ovarian endometriosis, adenomyosis and pelvic endometriosis, etc. It may also be caused by physiological reasons, which are handled differently for different reasons. Treatments include medication and surgery. In case of ovarian endometriosis and adenomyosis, drug treatment is available, aiming at inhibiting ovarian function, stopping the progression of ectopic disease, reducing the activity of endometriosis foci and decreasing the formation of adhesions, and the drugs available are mainly oral contraceptives and highly effective progesterone. In case of severe symptoms, surgical treatment can be taken according to the patient’s age and fertility requirements. If pelvic endometriosis is the cause, prostaglandinase synthesis inhibitors such as ibuprofen and indomethacin can be given to treat mild symptoms. If the symptoms are severe, laparoscopic electrosurgery of the endometriotic lesions can be done. Excluding organic diseases, consider primary dysmenorrhea, pay attention to rest and warmth during menstruation, do not eat spicy stimulation of cold and greasy food, menstrual pain can drink brown sugar ginger water, hot compresses and massage of the abdomen, if the pain is intolerable, you can take painkillers, such as ibuprofen extended-release capsules. The symptoms of thigh pain when menstrual cramps, after excluding physiological, should be timely medical treatment, so as not to delay the condition.