Blocking medications generally do not affect the window period for HIV. The window period is generally defined as 2-6 weeks, with the window period being the time between HIV infection and the time when infection can be detected and antibodies may be detected. Therefore, it is thought that most people can detect infection after six weeks. If the blocker fails to block, the virus in the body releases antigens and produces antibodies, and abnormal indicators, including antigens, antibodies, or viral nucleic acids, may be detected during the appropriate time period, and the window period will not be extended beyond the normal detection time period by the use of the blocker. In addition, the window period for HIV is a time frame of varying length, especially in some specific individuals. Therefore, it is necessary to assess the risk under the guidance of a doctor, take timely and effective blocking measures, and review the test regularly to rule out the possibility of viral infection.