Radiation burns are acute radiological skin injuries caused by a single exposure or multiple high doses of ionizing radiation within a short period of time. The first phase is the early reaction phase: it is characterized by temporary erythema of the irradiated area, and in severe cases, the early systemic reactions (headache, lethargy, nausea, vomiting, etc.) that occur in acute radiation sickness. The second phase is the pseudo-healing phase (also called the latent phase): the above local erythema fades and no other lesions appear on the surface, but the irradiated area still has functional disorders, temperature changes However, the irradiated area is still functionally impaired, with temperature changes, imbalance of sweat gland secretion, etc. If there is an early systemic reaction, it has disappeared by this time. The more severe the local and/or systemic injury, the shorter the pseudo-healing period. The third phase is the symptomatic period: the appearance of specific symptoms of varying degrees. Phase IV for the recovery period: this period of skin damage recovery, healing, or turn into a chronic lesion (at this time also known as the late reaction period). Radiation injury, according to the severity of its damage can be distinguished into four degrees. The clinical manifestations of the four degrees (mainly in the symptomatic period) are as follows: the first degree of hair loss reaction: the main damage to the skin’s accessory organs – hair follicles and sebaceous glands. The irradiated area initially appears spotty pigmentation with scattered corn-like follicular keratotic papules, centered on the hair follicle, higher than the skin surface, brownish in color, firmer and with a prickly feeling. Hair loss usually starts 2 weeks after irradiation and ends at the end of the third week; by the end of the third week, hair can be regenerated; if it does not grow within 6 months, it is mostly permanent hair loss. The second degree is the erythema reaction: this degree of injury has a clear clinical staging. Early reaction occurs a few hours after irradiation, local itching, pain, burning sensation and slight edema, and the appearance of clearly defined congestive erythema, lasting 1-7 d after the erythema disappears temporarily, and then enter the pseudo-healing period (latent period). During the pseudo-healing period, the clinical symptoms disappear but the local skin has dysfunction, which can last for about 3 weeks. Generally, it takes about 70d to enter the healing period. During this period, the skin should be protected from sun exposure, and if it occurs in radiation therapy, the next course of treatment should be carried out only after an interval of 60-70 d. The third degree is blistering reaction: the early reaction is similar to the second degree, but it appears early and heavy, and the pseudo-healing period usually does not exceed 2 weeks. Thereafter, persistent erythema appears, with significant local swelling, reddening of the skin, gradually becoming purplish red, itching, severe pain, and a severe burning sensation, and reduced skin sensibility. After a few days, blisters appear on the erythema, starting as small blisters and later fusing into large blisters with hyperpigmentation around them. The blisters break down and form a trabecular surface. After 1-3 months or more, the skin heals under a scab, leaving a partial scar. The fourth degree is ulcerative reaction: local burning or numbness occurs rapidly after irradiation, and pain, swelling and early erythema are significantly aggravated. The pseudo-healing period generally does not exceed 2-4 d. If the irradiation dose is particularly high, there may be no pseudo-healing period. When entering the symptomatic period, the erythema is reproduced, often greenish-purple, and soon blisters form, tissue necrosis, and trauma or ulcers appear. This ulcerative reaction to radiation burns is difficult to heal on its own, often experiencing months to years, and does not heal for a long time. After the third and fourth degree local skin radiation burns, there are mostly accompanied by systemic symptoms, which include systemic reactions to radiation injury and systemic reactions caused by local burn lesions. Even if the local lesions heal, late reactions may occur after several months or years, transforming into chronic cutaneous radiation injury.