Recurrent miscarriage is diagnosed when a woman has had two spontaneous abortions. If two or more spontaneous miscarriages occur, tests should be performed to identify the cause of the miscarriage. Generally about 50% of recurrent miscarriages can be detected by examination. The diagnosis and treatment of recurrent miscarriage is generally complex and requires specialized medical expertise.
The following tests are generally recommended for recurrent miscarriage.
(i) Female.
1.Sex hormone measurement
2. Thyroid function
3. Fasting blood glucose, glycosylated hemoglobin, lipids, liver and kidney function
4.Blood group (ABO+RH), coagulation function
5.Chromosome
6.Vaginal secretions: mycoplasma, chlamydia
7.TORCH
8, Autoantibodies: anti-cardiolipin antibody, anti-nuclear antibody, anti-double-stranded DNA antibody, anti-β2GPI antibody, closed antibody
9.Lupus anticoagulant, S protein, C protein, antithrombinogen III
10.Vaginal ultrasound, hysteroscopy if necessary
(B) Male side.
1.Semen routine + morphology + DNA fragmentation
2.Chromosome
3.Blood group (ABO+RH)
(iii) Aborted embryo: chromosome core analysis or gene chip examination
Relevant symptomatic treatments that can be performed based on the above tests.
(1) Related departments to treat their own diseases: e.g. blood glucose, nail function abnormalities
(2) Luteal support, fetal preservation
(3) Treatment of infectious diseases: e.g. Chlamydia infection
(4) Immunotherapy: prednisone, cyclosporine, closed antibody immunotherapy
(5) Anticoagulation therapy: aspirin, heparin
(6) Surgery for uterine malformations
(7) PGS screening for normal embryos