The mechanism of antibacterial action of cephalosporins is similar to that of penicillin, which belongs to the reproductive phase bactericidal agent and is a time-dependent antibacterial drug and should be given in daily doses. Cephalosporins are currently divided into five generations: the representative drugs of the first generation include cefradine, cefazolin and cefadroxil; the representative drugs of the second generation include cefuroxime, cefotiam and cefaclor; the representative drugs of the third generation include ceftazidime, ceftriaxone and cefoperazone; the representative drugs of the fourth generation of cephalosporins include cefepime; the representative drugs of the fifth generation include ceflorin esters, cefotoro and cefepime. Cephalosporin antibiotics from the first generation to the fifth generation, the toxicity to the kidney gradually weakened, the fourth generation of cephalosporins class has no toxicity to the kidney, the fourth generation and the fifth generation of cephalosporins belong to the broad-spectrum antibacterial drugs, the activity of Gram-positive bacteria began to enhance, to Gram-negative bacteria, Pseudomonas aeruginosa, Enterobacter spp. have good antibacterial effect.