Toothache can be relieved by taking painkillers, but painkillers cannot cure toothache, patients need to seek medical treatment to completely relieve the symptoms. Toothache is oral ibuprofen can be temporary pain relief. If it is an acute attack of pulpitis, no medication can effectively relieve the pain. The pain of pulpitis is very severe, especially at night and even waking up from sleep. Dental treatment is necessary. In pulp infection the pressure inside the pulp cavity increases and the pulp cavity is surrounded by hard dental hard tissues, making it difficult for medications to relieve the severe pain. In the acute stage, open pulp drainage is performed to relieve the pressure and the pain can be relieved naturally. Therefore, oral ibuprofen for toothache can provide temporary relief, and pulp drainage to relieve the pressure in the pulp cavity can provide quick pain relief. A visit to the dentist is required. Drugs should be used under the supervision of a physician.