Neonatal jaundice should be considered pathologic when the following conditions occur: first, jaundice occurs within 24 hours after birth, with a total bilirubin value of more than 6mg/dl. second, jaundice peaks at a total bilirubin value of more than 13mg/dl in full-term infants, and more than 15mg/dl in preterm infants. third, serum-conjugated bilirubin value of more than 1.5mg/dl. fourth, total bilirubin value rises more than 5mg/dl every day. fifth, jaundice lasts for more than 2-4 weeks, or worsens or recurs after a period of time. Fifth, the duration of jaundice is too long, more than 2-4 weeks, or the jaundice is progressively worsening or recurring. The above conditions should be considered as the possibility of pathologic jaundice.