The causes of lupus erythematosus are complex and not yet fully understood, and may be related to genetics, environment, medication, sex hormone infection and other factors. Lupus erythematosus is divided into systemic lupus erythematosus and cutaneous lupus erythematosus, which is a kind of autoimmune disease that involves multiple organs and systems. The causes of this disease are complicated and not yet fully understood, which may be related to genetics, the environment, medications, sex hormone infections and other factors, among which systemic lupus erythematosus has an obvious tendency of family aggregation. The prevalence of SLE is significantly higher in women than in men. Ultraviolet radiation may also induce or aggravate lupus erythematosus, and drugs such as biologics, penicillin and isoniazid may induce pharmacologic lupus. In addition, EBV infection, streptococcal infection, cold stimulation, trauma, endocrine disorders, mental stress, overwork and other factors are also associated with the development of lupus erythematosus. It is recommended that lupus patients go to the rheumatology and immunology department of regular hospitals for detailed consultation and follow the doctor’s instructions for treatment.