Spirochete infection generally refers to syphilis spirochete infection, which is a chronic systemic infectious disease. The mode of transmission of syphilis spirochetes includes sexual contact, placental transmission, blood transmission, etc. Therefore, to prevent syphilis infection, it is recommended to keep regular sexual partners, not to have sex with syphilis infected persons, strengthen pre-marital and prenatal checkups, etc., and try to minimize contact with syphilis infected persons, such as kissing, etc., as well as timely disinfection of clothing and utensils and use them separately. Women infected with syphilis are advised to take relevant contraceptive measures, and when the syphilis titer becomes negative or stays at a low titer after treatment, they can prepare for pregnancy under the guidance of a physician. If a pregnant woman is infected with syphilis spirochetes, she should be treated with mother-to-child interruption during pregnancy to prevent the spirochetes from passing through the placenta and infecting the fetus, causing congenital syphilis. Once the diagnosis of spirochete infection is confirmed, it is necessary to consult a doctor in a timely manner, further testing to clarify the degree of spirochete infection, follow the doctor’s instructions to take antibiotics such as benzylpenicillin and other antibiotics, and regularly do syphilis antibody tests.