The incidence of pancreatic cancer has been increasing significantly worldwide, and the incidence in China has also increased significantly in the last decade. In the United States, there were 29,200 new cases of pancreatic cancer in 2001, and about 28,900 people died from pancreatic cancer, whose incidence rate has exceeded that of stomach cancer. In Shanghai, during the 20 years from 1980 to 2000, the incidence and mortality of pancreatic cancer in Shanghai rose from the 10th place to the 8th and 6th place in the tumor parity, and the incidence and mortality rate increased by about 50%. Pancreatic cancer is not easily diagnosed at an early stage, and when it is found, it is mostly in the middle and late stages, and the previous surgical resection rate is only 10%-20%, while its malignant degree is high, and the metastasis rate of liver and lymph nodes is high, and it is not sensitive to radiotherapy and chemotherapy. Therefore, it is called “the king of cancer” and “the cancer of the 21st century”. There are no characteristic symptoms in the early stage of pancreatic cancer. The first symptoms, such as pain in the upper abdomen, fullness and distension, loss of appetite, etc. are easily confused with common diseases of the digestive tract, such as gastrointestinal, hepatobiliary diseases, which are not easy to attract the attention of patients and clinicians, and the neglect of relevant examinations for pancreatic tumors is an important reason for delaying the diagnosis. It is often difficult to obtain long-term survival when jaundice, severe low back pain, wasting, weakness and other mid- to late-stage clinical manifestations appear. Therefore, to improve the early diagnosis rate of pancreatic cancer, it is necessary to first enhance the vigilance of pancreatic cancer. The following conditions are considered as high-risk groups for pancreatic cancer and should be alerted to the possibility of pancreatic cancer: (1) those who have symptoms such as upper abdominal pain, bloating and abdominal discomfort over 40 years of age, and gastroscopy and ultrasound do not reveal common upper gastrointestinal diseases such as gastric disease and cholecystitis, should be alerted to the possibility of pancreatic disease; (2) those who have a family history of pancreatic cancer: pancreatic cancer has a hereditary tendency, and if parents have a history of pancreatic cancer, they should also (3) Patients with sudden onset diabetes, especially those without a family history of diabetes and diabetes-prone factors such as obesity, who develop insulin resistance soon after onset (high blood glucose, which is not easily controlled by insulin); (4) Recurrent chronic pancreatitis, especially chronic familial pancreatitis and chronic calcific pancreatitis. (5) Acute pancreatitis attacks of unknown origin. It manifests as sudden onset of upper abdominal pain, and the diagnosis of acute pancreatitis is made when the blood and urine amylase is found to be elevated at the hospital visit. If there is no common cause of acute pancreatitis such as biliary tract disease, alcohol consumption, hyperlipidemia, etc., a comprehensive examination should be done to target pancreatic cancer. In our clinic, we found that about 15% of patients with pancreatic cancer have acute pancreatitis as their first symptom.