Topical sprays are effective in treating premature ejaculation, but they are not recommended for long-term use. Objectively speaking, topical sprays have a certain effect on the treatment of premature ejaculation, but this kind of drug can’t completely cure premature ejaculation. Topical sprays are a temporary local anesthetic, coated or sprayed on the glans, can anesthetize neuron cells, so that the neurotransmitters responsible for transmitting pleasure can not stimulate the nerve synapses, so as to achieve prolonged ejaculation time, improve the phenomenon of premature ejaculation. Although topical sprays can improve premature ejaculation and prolong ejaculation time in a short period of time, long-term use may reduce sexual pleasure, and may also make the sensitive nerves of the penis lose their ability to regulate, resulting in delayed or difficult erection, making premature ejaculation more serious. Patients who want to treat premature ejaculation are advised to go to a regular hospital for a detailed examination to find out the cause of the disease, and then carry out the correct treatment under the guidance of the doctor, and not to use medication privately, so as not to aggravate the condition.