The leopard sign is an image concept of breast ultrasound, which is formed by the action of multiple components such as fatty connective tissue and multiple interfaces on the sound waves in the breast, and can be localized or distributed as a whole. It can be localized or distributed as a whole. It appears as patches and strips of hypoechoic and hyperechoic intertwined, resembling the pattern of a leopard’s skin, and is therefore called the leopard’s sign echogenicity. The leopard sign in the breast is mostly suggestive of breast hyperplasia, but the ultrasound diagnosis of breast hyperplasia is poorly reproducible and highly subjective.