Liver metastasis in January after duodenal cancer surgery should be treated with chemotherapy, radiotherapy and painkillers as prescribed by doctors. 1. Chemotherapy: liver metastasis of duodenal cancer indicates that the condition is more serious and the possibility of cure is relatively small, so chemotherapy such as irinotecan and other drugs can be chosen to alleviate the pain of patients. 2. Radiotherapy: α, β, γ rays produced by radioactive isotopes and x-rays, electron beams, proton beams and other particle beams produced by various kinds of x-ray therapy machines or gas pedals can be used to treat the localized cancer cells. 3. Painkiller treatment: Oral cancer analgesics such as pethidine hydrochloride are taken to cooperate with the treatment to relieve patients’ pain symptoms and improve the quality of life. If there is metastasis of cancer cells after duodenal cancer surgery, it is necessary to face it positively, and it is recommended to carry out standardized treatment as early as possible to reduce the adverse effects of the disease.