Rabies vaccine booster shots generally produce a large amount of antibodies within a month after the shot, and the concentration of antibodies can reach 20 U/mL. Usually, antibodies above 0.5 U/mL in the body can play a role in protection from the virus. After 5 full doses of rabies vaccine, the body is generally considered to be protected from the virus for one year. If the rabies vaccine has been administered for a longer period of time, it is possible that the body may have less than 0.5 U/mL of antibodies, and a booster shot is required immediately. After the booster shot, it is best to inject anti-rabies immune globulin again as a precaution. Rabies is a malignant infectious disease that mainly infects the nervous system. Once infected, there is no cure and the mortality rate is 100%. After rabies vaccination, redness, swelling and pain at the inoculation site may occur, and some people may develop hard nodes and peripheral edema of the injected limb, which can generally be relieved on their own and do not require treatment. Do not take a shower on the day of vaccination to avoid infection at the vaccination site.