The appearance of weakness of limbs and chest tightness and shortness of breath may be a manifestation of acromegaly, and may also be related to lung diseases such as pulmonary fibrosis, cardiovascular diseases such as heart failure, and severe anemia. 1. Acromegaly: Acromegaly is a chronic progressive neurodegenerative disease. Patients usually have an insidious onset and the disease progresses slowly. Most patients may have progressive aggravation of skeletal muscle weakness, atrophy, muscle fasciculations and other manifestations, which may be accompanied by weakness, chest tightness, shortness of breath and other symptoms with the development of the disease. 2. Pulmonary fibrosis: it is mainly manifested as dyspnea, cough, fatigue, weight loss and so on. Therefore, patients with weakness of limbs, chest tightness and shortness of breath may be caused by pulmonary fibrosis. 3. Heart failure: heart failure is divided into left heart failure and right heart failure, and left heart failure is mainly manifested as a syndrome caused by pulmonary circulation stagnation and reduced cardiac output, such as dyspnea, lethargy, fatigue, and loss of physical strength. Patients with left heart failure may cause symptoms of limb weakness, chest tightness and shortness of breath. 4. Severe anemia: Severe anemia refers to the severe lack of red blood cells in the peripheral blood of the human body, and its main manifestations are dizziness, chest tightness, shortness of breath, general weakness, insomnia, dreamy and other symptoms. When suffering from severe anemia, it may cause weakness of limbs, chest tightness and shortness of breath. In addition, coronary heart disease, poisoning, myasthenia gravis and other diseases may also cause such symptoms, it is recommended that patients seek timely medical examination to clarify the cause of the disease and then targeted treatment.