The effect time of the first dose of antihypertensive drugs is related to the type of antihypertensive drugs. There are more types of antihypertensive drugs, which can be divided into short-acting antihypertensive drugs and long-acting antihypertensive drugs according to their half-lives. Long-acting antihypertensive drugs have a longer half-life, taking 1-2 days to start taking effect, with the effect gradually increasing in 3-5 days, and the effect may reach its peak in 2-4 weeks. Therefore, the effect is not immediate after taking antihypertensive drugs, blood pressure needs to drop gradually and steadily, hypertensive patients should first observe and follow the doctor’s instructions after taking the medication. In addition, antihypertensive drugs have certain side effects, and the dose can be reduced when taken in combination to reduce the side effects, but the specific type and mode of medication should follow medical advice.