If the patient still has headache after taking painkillers, it means that the patient’s headache is heavy and has a certain tolerance to the drug and the effect is not good. In this case, it is recommended that the patient should consult a hospital to improve the medical examination, to clarify the cause of the headache, and to treat the cause for good results. 1. If the headache is caused by serious diseases, such as subarachnoid hemorrhage or brain tumor, the patient’s headache will not be relieved even after taking painkillers, but will lead to the patient’s condition being delayed, so timely consultation is necessary to treat the cause. 2. If the headache is functional and the patient still has headache after taking painkillers, there is no relief. In this case, it is necessary to adjust the drugs, such as migraine, you can take specific painkillers, such as sumatriptan, zolmitriptan, ergotamine caffeine, which are specific drugs with good effect in relieving headache.