CNS lymphoma is not completely cured by radiotherapy.
There are primary and secondary CNS lymphomas. Primary CNS lymphoma is a highly malignant non-Hodgkin’s lymphoma with poor prognosis, and high-dose methotrexate chemotherapy combined with radiotherapy is the commonly used treatment plan at present, and rituximab can also be added. Secondary central nervous system lymphoma is mostly in the advanced stage of lymphoma, and the treatment effect is poor.
Due to the existence of blood-brain barrier, many large molecule drugs are difficult to cross the blood-brain barrier, and the therapeutic effect is poor, so for central nervous system lymphoma is usually a combination of chemotherapy and radiotherapy.
Current clinical practice has shown that administration of high-dose methotrexate followed by an adjuvant whole-brain radiotherapy regimen has not improved patient survival and prognosis overall. Neurotoxicity caused by radiotherapy may lead to patient death, so for CNS lymphoma, it is not curable by radiotherapy.