The reason why the two sides of the cheeks long acne, may be associated with sebaceous gland secretion, may also be due to endocrine disorders, microbial infections and other reasons. 1. Excessive sebaceous gland secretion: common in adolescents, because in adolescence, sebaceous gland secretion is exuberant, easy to cause local follicle pore obstruction, resulting in excessive sebaceous gland can not be discharged in a timely manner, which may lead to the two sides of the cheeks long acne. 2. Endocrine disorders: usually due to long-term poor mood, excessive late-night and other reasons, due to endocrine disorders, may cause acne on both sides of the cheeks. 3. Microbial infection: usually due to poor local hygiene, or the abuse of cosmetics, did not pay attention to the reasonable make-up removal, it is easy to cause local microbial infections and the formation of skin inflammation, which may cause acne on both sides of the cheeks, commonly found in the Malassezia bacteria, Propionibacterium acnes infection. Acne on both sides of the cheeks may also be caused by other reasons, it is recommended to consult a doctor as soon as possible to clarify the causes, and then give targeted treatment and adjustment.