Rabies, also known as hydrophobia, is an acute human-animal infectious disease caused by the rabies virus. Rabies virus is mainly transmitted between animals. The main sources of rabies infection are dogs, cats, pigs, cattle, and horses with rabies viruses. The disease is primarily contracted through the invasion of rabies virus in the saliva of animals that bite humans. Once rabies develops, it progresses rapidly, mostly in 3-5 days, rarely in more than 10 days, with a 100% mortality rate. Whether or not a dog bite causes rabies is influenced by many factors: 1. whether the dog that bit the person has the rabies virus. 2. The degree of wound exposure. 3, the treatment of the exposed wound. 4, rabies vaccine, rabies immunoglobulin injection. A dog bite does not necessarily result in rabies. If the dog that bites a person does not have rabies virus, the person will not get rabies even if the wound is not treated. Some scholars have found that only 30%-70% of people who are bitten by a real rabid dog or other crazy animal and do not take any preventive measures develop rabies as a result. The main source of rabies infection in China is sick dogs, some seemingly healthy dogs can carry the virus in their saliva, with a rate of up to 22.4%, can also spread rabies. And there is a lack of methods to detect whether dogs carry the virus, so once bitten or scratched by a pet such as a dog or cat, the wound should be cleaned immediately. The severity of the bite affects whether the person who was bitten develops the disease. Large deep bites are easier to develop than superficial wounds with small wounds; multi-part bites are also easier to develop than single-part bites, and the incubation period is shorter. Wound treatment: 1, squeeze the wound: try to squeeze the bleeding or cupping with a fire can, avoid sucking the wound with your mouth to prevent oral mucosa infection; 2, rinse the wound: repeatedly rinse with 20% soap and water or 0.1% Neosporin for at least 15 minutes, quaternary amines and soap and water can not be used together; 3, disinfect the wound: scrub with 70% alcohol and repeatedly coated with concentrated iodine; local wounds in principle, no sutures, no bandages, no ointment If the head and face are injured, or the wound is large and deep, and the large blood vessels need to be sutured and bandaged, it should be done in such a way that it does not hinder drainage, ensure adequate flushing and disinfection, and rabies immunoglobulin local infiltration injection can be sutured after 2 hours, and tetanus antitoxin can be used at the same time. Rabies vaccination should be administered after wound treatment. Post-exposure prophylaxis: 5 doses of rabies vaccine should be given on days 0 (day of injection), 3, 7, 14, and 28 (same dosage for children). Rabies vaccination must be completed on time for the full course of immunization. Failure to receive the full course of vaccination will not ensure adequate anti-rabies immunization and rabies prevention is not guaranteed. Rabies vaccine is given in one dose per dose regardless of weight and age. For those who have received full immunization within six months, if suspicion of infection occurs, there is no need to inject rabies vaccine again; for those who have received full immunization over six months but within one year, if suspicion of infection occurs, only one intramuscular injection is needed on each of the 0 and 3 days. If immunized for more than one year but within three years, an intramuscular injection is required on 0, 3 and 7 days; if immunized for more than three years, a full immunization is required. If the injection is given more than 48 hours after the bite, it is recommended that the first dose be doubled. Rabies vaccination should be given at the same time to those with bleeding wounds or those without bleeding wounds but who are immunocompromised. Proper and timely wound treatment after a bite is the first line of defense against rabies, and if the wound is properly treated and treated promptly with anti-rabies post-exposure therapy (vaccination and immunoglobulin), the risk of morbidity can be greatly reduced.