Imaging-guided collagenase discolysis for herniated disc Chronic neck, shoulder, lumbar, and leg pain is mostly caused by herniated discs, the pathogenesis of which lies mainly in degenerative changes of the discs, trauma, and strain. The diseased disc protrudes into the posterior spinal canal or ruptures and causes leakage of disc fluid, resulting in irritation or compression of adjacent tissues such as spinal nerve roots and spinal cord in the spinal canal, resulting in clinical symptoms such as lumbar pain and unilateral or bilateral leg pain and numbness. Many people have clinical symptoms but no obvious abnormalities on imaging (this is mostly due to degeneration and rupture of the fibrous ring causing inflammatory material to gather), and for a long time people have often had to take the approach of enduring this lifelong pain, and opening their mouths to cry out in pain is considered a sign of immaturity and lack of strength, and a few people are also mistaken for psychiatric abnormalities. Traditional treatment is mostly based on surgery, which is feared by patients because of the large surgical incision, extensive tissue stripping, bleeding, inevitable soft tissue damage, bone damage, disruption of spinal stability, bed rest and long postoperative recovery time, and the more common adverse effects of nerve adhesions or adhesions in the epidural space. Patients with cervical and lumbar disc herniation desire an ideal method that is non-invasive, less invasive, less painful, quicker to recover, more effective, safer and simpler. Collagenase, whose full name is collagen hydrolase, can dissolve collagen, the main component of intervertebral discs, and release the herniated discs from nerve compression, while not acting on other structures and tissues such as bone and nerve roots, which is a minimally invasive interventional therapy developed in recent years. However, if the positioning is not accurate, the collagenase will not reach the intervertebral disc and the therapeutic effect will be poor, and if the injection site is wrong, an accident will easily occur. With advanced imaging and electrophysiology equipment, our department has taken the lead in carrying out combined imaging-electrophysiology-guided neurointerventional minimally invasive collagenase therapy, which can accurately deliver collagenase to the diseased disc herniation site, and has effectively eradicated the disease for many patients with neck, shoulder, lumbar and leg pain, while avoiding the danger of blindly injecting collagenase and greatly improving the safety of treatment. Trigeminal neuralgia is a recurrent transient and severe pain involving one or several branches of the trigeminal nerve in the face. Although the diagnosis of this disease is relatively easy, the treatment is very difficult, and many patients are in pain and commit suicide. Our department is the first in China to carry out CT-neurophysiology combined navigation and localization trigeminal neuralgia radiofrequency treatment, under the precise navigation of CT combined with electrophysiological detection, the tiny radiofrequency needle is sent into the trigeminal nerve hemimelia through the oval hole, giving selective moderate thermal coagulation destruction, blocking the conduction of pain signals within the nerve, thus eliminating pain, avoiding the shortcomings of the past blind puncture with poor efficacy and many complications. It is an effective method for the treatment of trigeminal neuralgia, with the advantages of being economical, simple and less invasive. Minimally invasive neurointerventional treatment for herpes zoster neuralgia Herpes zoster is a viral infection of the skin that develops along the innervated skin and is accompanied by neuralgia. It is called “herpes zoster” because the virus is nerve-friendly and always develops in strips along the nerves, hence the name “herpes zoster”. It is called “herpes zoster” because the virus is nerve-friendly and always develops along the nerves in a band-like pattern. Our department adopts minimally invasive neurointerventional surgery, which can effectively treat post-herpetic neuralgia by using intra-vertebral micro-continuous drug delivery combined with selective nerve destruction under the guidance of CT or C-arm X-ray machine. Combined imaging-neurophysiology-guided neurointerventional minimally invasive cancer pain treatment About 85% of advanced cancer patients have severe pain, which seriously affects patients’ survival quality and treatment of primary disease, and 10-20% of them have intractable cancer neuralgia that cannot be relieved by morphine and other drugs, which makes patients feel so painful that they commit suicide or seek “euthanasia The pain is so unbearable that patients commit suicide or seek “euthanasia”. Cancer pain is also a dynamic development process. As the disease progresses, the patient’s psychological, social and spiritual conditions change, and the central nervous system may also show neuroplasticity changes, which makes the pain abnormally stubborn and extremely painful for patients and family members. Our department uses combined imaging-neurophysiology-guided neurointerventional minimally invasive cancer pain treatment technology to relieve pain and improve the quality of life for cancer pain patients. Other special treatment – post-paraplegic neuralgia, brachial plexus nerve (post-injury/post-surgery) neuralgia, post-surgical pain syndrome of cervical and lumbar disc herniation.