Helicobacter pylori infection requires strict selection of antibacterial drugs for bactericidal treatment, Western drugs in order to achieve the effect of killing Helicobacter pylori; traditional Chinese medicine treatment is poor. Helicobacter pylori infection is a high-risk factor for the development of chronic dyspepsia, chronic gastritis, gastric cancer and other digestive diseases. When Helicobacter pylori infection is detected, it needs to be treated strictly according to the standard antimicrobial program for bactericidal treatment, with western medicine as the main means of treatment, and traditional Chinese medicine has no bactericidal effect. Clinicians often use a four-pronged program for H. pylori treatment, which consists of two antibiotic drugs + a proton pump inhibitor + a bismuth agent. Antibiotic drugs can choose amoxicillin capsules, tetracycline, metronidazole and clarithromycin, etc.; proton pump inhibitors can choose omeprazole, pantoprazole, lansoprazole or rabeprazole, etc.; bismuth can choose colloidal bismuth pectin or bismuth potassium citrate, etc.. When discovering Helicobacter pylori infection, it should be treated in time under the guidance of professional physicians to formulate a suitable bactericidal program, and it is necessary to consult the advice of professional physicians when using medication.