The baby’s high fever does not go down to take antipyretic medicine is useless, can be seen in the failure to use a reasonable dose of antipyretic medicine, observation time is not appropriate or disease-related factors, etc., the intervention needs to be based on the cause of the decision, such as the reasonable use of antipyretic medicine, in the right time to observe the body temperature and drug therapy. 1. Failure to use reasonable doses of antipyretics: For babies with high fever who need to use antipyretics, such as ibuprofen or acetaminophen, if the dosage is not correct, the antipyretic effect may be unsatisfactory. These babies should be given the right dose of antipyretics according to their weight under the guidance of a physician. 2. Improper observation time after the use of antipyretics: It is generally believed that the body temperature can gradually decline in about 30 minutes after the use of antipyretics, and some babies in the acute stage of the disease may have their body temperature gradually decline only after 2~3 hours of the use of antipyretics, and the observation time is less than the above phenomenon may occur. For such babies can use warm water wipe or warm water bath to reduce fever, and continue to monitor the body temperature. 3. Disease-related factors: If the disease is in the acute stage or the condition is critical, the above phenomenon may occur, such babies need to actively seek medical attention, and the specialist physician to re-assess the condition. If the above phenomenon occurs in severe pneumonia, sepsis and other diseases, it is necessary to strengthen the anti-infection efforts, and the use of glucocorticosteroids, such as methylprednisolone sodium succinate and other appropriate treatment. All of the above medications should be used under medical supervision, and active consultation is recommended for appropriate intervention after evaluation by a specialist.