The painkillers that can be taken by gallstone patients include diclofenac sodium, ketoprofen and indomethacin. Most patients with gallstones have no obvious symptoms, but a small number of patients will experience recurrent vague pain in the right upper abdomen or symptoms of biliary colic. For the pain caused by gallstones, patients can usually take non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac sodium, ketoprofen, indomethacin, etc., as prescribed by the doctor for pain relief. Some patients can also take scopolamine and other antispasmodic drugs to assist in pain relief. If gallstones patients with severe pain, pain persists without relief and other symptoms, the strict application of dulcolax, bupropion and other strong analgesic drugs as prescribed by the doctor. For gallstones that are large in size and serious in condition, they should be treated in time through open surgery, laparoscopic cholecystectomy and other surgical methods to achieve complete treatment of the disease and pain relief. It is recommended that people with gallstones accompanied by pain should follow the doctor’s instructions to use medication, and should not use drugs or prescriptions indiscriminately to prevent aggravation of the condition. Gallstones patients should pay attention to regular medical review, strengthen the dietary care.